Shunichi Shiozawa Selected Research

3- (5- (4- (cyclopentyloxy)- 2- hydroxybenzoyl)- 2- ((3- hydroxy- 1,2- benzisoxazol- 6- yl)methoxy)phenyl)propionic acid

1/2018	A selective c-Fos/AP-1 inhibitor prevents cartilage destruction and subsequent osteophyte formation.
12/2017	A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain.
5/2016	Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model.
1/2015	T-5224, a selective inhibitor of c-Fos/activator protein-1, improves survival by inhibiting serum high mobility group box-1 in lethal lipopolysaccharide-induced acute kidney injury model.
5/2012	Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.

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Shunichi Shiozawa Research Topics

Disease

36	Neoplasms (Cancer) 02/2022 - 04/2003
20	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 05/2007
20	Rheumatoid Arthritis 01/2018 - 08/2004
18	Neoplasm Metastasis (Metastasis) 02/2022 - 03/2005
9	Stomach Neoplasms (Stomach Cancer) 02/2022 - 11/2013
9	Lymphatic Metastasis 10/2021 - 01/2008
8	Esophageal Neoplasms (Esophageal Cancer) 12/2020 - 07/2008
6	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2022 - 09/2004
6	Rectal Neoplasms (Rectal Cancer) 01/2021 - 05/2007
6	Colonic Neoplasms (Colon Cancer) 10/2020 - 01/2008
6	Pathologic Constriction (Stenosis) 12/2019 - 11/2013
5	Pancreatic Neoplasms (Pancreatic Cancer) 12/2018 - 01/2003
4	Sigmoid Neoplasms 12/2018 - 11/2014
4	Pain (Aches) 12/2017 - 12/2002
4	Autoimmune Diseases (Autoimmune Disease) 01/2014 - 12/2009
3	Thrombosis (Thrombus) 12/2021 - 11/2009
3	Disease Progression 10/2021 - 10/2016
3	Wounds and Injuries (Trauma) 10/2019 - 03/2014
3	Hepatocellular Carcinoma (Hepatoma) 01/2016 - 11/2009
3	Acute Kidney Injury (Acute Renal Failure) 01/2015 - 11/2012
3	Arthritis (Polyarthritis) 02/2010 - 07/2008
2	Inflammation (Inflammations) 01/2022 - 12/2012
2	Cecal Neoplasms 10/2019 - 02/2018
2	Glomerulonephritis 01/2019 - 07/2013
2	Head and Neck Neoplasms (Head and Neck Cancer) 12/2018 - 05/2016
2	Residual Neoplasm 10/2018 - 07/2008
2	Necrosis 02/2018 - 12/2012
2	Osteoarthritis 01/2018 - 03/2006
2	Hemorrhage 10/2017 - 11/2008
2	Ileus 11/2015 - 11/2013
2	Peritonitis 11/2014 - 09/2004
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 05/2014 - 01/2007
2	Carcinoma (Carcinomatosis) 11/2013 - 01/2007
2	Bile Duct Neoplasms (Bile Duct Cancer) 07/2008 - 03/2004
2	Adenocarcinoma 01/2008 - 01/2007
2	Hypesthesia (Numbness) 11/2007 - 12/2002
2	Osteoporosis 05/2005 - 04/2005
1	Ataxia (Dyssynergia) 02/2022
1	Weight Loss (Weight Reduction) 10/2021
1	Body Weight (Weight, Body) 04/2021
1	Respiratory Sounds (Crackle) 01/2021

Drug/Important Bio-Agent (IBA)

10	Bevacizumab (Avastin)FDA Link 11/2021 - 11/2013
9	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 12/2017 - 08/2004
7	Fluorouracil (Carac)FDA LinkGeneric 10/2018 - 04/2003
6	Methotrexate (Mexate)FDA LinkGeneric 02/2016 - 01/2005
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2015 - 07/2008
5	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2022 - 11/2013
5	Proteins (Proteins, Gene)FDA Link 10/2020 - 03/2006
5	CytokinesIBA 01/2018 - 07/2008
5	3- (5- (4- (cyclopentyloxy)- 2- hydroxybenzoyl)- 2- ((3- hydroxy- 1,2- benzisoxazol- 6- yl)methoxy)phenyl)propionic acidIBA 01/2018 - 05/2012
5	Cisplatin (Platino)FDA LinkGeneric 11/2013 - 04/2003
4	Serum AlbuminIBA 04/2021 - 11/2013
4	Therapeutic UsesIBA 02/2020 - 05/2016
4	AutoantibodiesIBA 01/2019 - 07/2013
4	Matrix Metalloproteinases (MMPs)IBA 01/2018 - 07/2008
4	Pharmaceutical PreparationsIBA 12/2017 - 04/2003
4	Leucovorin (Folinic Acid)FDA Link 10/2016 - 05/2007
4	Gemcitabine FDA Link 11/2008 - 04/2003
3	Panitumumab (Vectibix)FDA Link 01/2021 - 11/2013
3	AntigensIBA 01/2014 - 12/2009
2	Capecitabine (Xeloda)FDA Link 11/2021 - 11/2013
2	regorafenibIBA 10/2021 - 10/2019
2	SteroidsIBA 01/2021 - 09/2004
2	trifluridine tipiracil drug combinationIBA 10/2019 - 10/2015
2	Antigen-Antibody Complex (Immune Complex)IBA 01/2019 - 07/2013
2	Irinotecan (Camptosar)FDA LinkGeneric 02/2018 - 01/2008
2	Member 25 Tumor Necrosis Factor ReceptorsIBA 01/2018 - 03/2006
2	Amylases FDA Link 11/2017 - 11/2005
2	Antirheumatic Agents (DMARD)IBA 02/2016 - 06/2012
2	Biological ProductsIBA 02/2016 - 12/2010
2	Peptides (Polypeptides)IBA 10/2011 - 11/2008
2	Etanercept (Enbrel)FDA Link 08/2011 - 12/2010
2	Phosphotransferases (Kinase)IBA 02/2010 - 09/2005
2	DNA (Deoxyribonucleic Acid)IBA 03/2006 - 04/2005
1	AutoantigensIBA 01/2022
1	Immunologic Factors (Immunomodulators)IBA 10/2021

Therapy/Procedure

27	Drug Therapy (Chemotherapy) 12/2021 - 04/2003
23	Therapeutics 12/2021 - 09/2004
8	Gastrectomy 02/2022 - 11/2015
8	Adjuvant Chemotherapy 01/2022 - 01/2008
5	Colectomy 10/2021 - 11/2013
5	Esophagectomy 02/2019 - 01/2007
4	Pancreaticoduodenectomy 11/2017 - 01/2003
3	Stents 12/2019 - 11/2013
3	Colostomy 02/2018 - 11/2015
3	Lymph Node Excision (Lymph Node Dissection) 01/2018 - 01/2007
3	Punctures 12/2017 - 12/2002
3	Neoadjuvant Therapy 11/2013 - 07/2008
2	Length of Stay 10/2021 - 10/2014
2	Laparotomy 10/2018 - 10/2017
2	Suction (Suction Drainage) 01/2018 - 03/2014
2	Radiotherapy 11/2017 - 05/2007
2	Operative Time 10/2017 - 10/2017
2	Laparoscopic Cholecystectomy 07/2008 - 11/2005
1	Craniotomy 02/2022
1	Gastroenterostomy 02/2022
1	Pancreatectomy 12/2021
1	Perioperative Period 10/2021
1	Total Parenteral Nutrition 04/2021
1	Premedication 01/2021